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Discussion in 'Ask the Vet' started by yarnammurt, Jul 22, 2013.
is it safe to use on dogs. I have 6 large breed dogs and I was told I could use it.
My buddy uses his left overs on his dogs.
1mL per 10lbs. That's what we've always done.
Originally Posted by gunslinger View Post
Ivermectin Only Prevents Heartworms and 3 types of Hookworm in Dogs (Canines) A caninum, A braziliense, U stenocephala . That’s ALL the Parasites this Medication Will Prevent/Control/Kill in DOGs
The Total Dosage of Ivermectin Required to Prevent Heartworms is .006 Mg per # of Dog Weight .. i.e.: a 50# dog would receive a Dosage of .03 MG of 1% Ivermectin Solution or .03 CC/ML .. If you Use a Insulin Syringe which is only 1cc/ml it would be the 3rd. mark ..
At this Exact same Dosage of Ivermectin it will control and Kill 2 species of Hookworm in Canines A braziliense, U stenocephala, to Kill and Control A caninum at a 97% rate it requires a Dosage of .0122 Mg per # of Dog Weight .. I.e.: a 50# dog would receive a Dosage of .61cc/ml .. At this Point It much Better to Use Fenbendazole (SafeGuard or Pancur) or Pyrantel pamoate (Nemex 2 )
Efficacy of ivermectin against Ancylostoma caninum and Uncinaria stenocephala in dogs.
Daurio CP, Roberson EL, Seward RL.
Merck Research Laboratories, Rahway, New Jersey 07065.
The effective dosage of a chewable formulation of ivermectin was determined in 35 young dogs with induced infections of Ancylostoma caninum and Uncinaria stenocephala. Dogs were inoculated with these parasites and held until the infections were patent. Within each of 7 replicates, dogs were allocated randomly to 1 of 5 treatment groups: vehicle control, or ivermectin at 6, 12, 18, or 24 micrograms/kg. Chewable treatments were tailored to body weight. Seven or 8 days after treatment, parasites were recovered using standard techniques. All 7 controls had adult A. caninum (geometric mean = 35.5) and U. stenocephala (geometric mean = 82.6). Against A. caninum, the efficacy of ivermectin was 52%, 98%, 95%, and 97% at 6, 12, 18, and 24 micrograms/kg, respectively. The statistical model that best described the dose response was linear to 12 micrograms/kg with a plateau thereafter. Using this model, the estimated reduction from the predicted control mean was 97.2%; the estimated dose to eliminate 90% of the worms (ED90) was 8.4 micrograms/kg, and the ED95 was 10.5 micrograms/kg. Against U. stenocephala, the dose response was linear in the range studied, with an ED90 of 20.8 micrograms/kg; it was estimated that 93.2% of the worms would be eliminated.
For the Fokes that Think that the Horse Wormers / Paste is the End All to All Worms ...
Zimecterin Gold ... Measured at the same weights noted on the Tube contains .091 Mg per Pound of Ivermectin and the Maxium Dosage of For a Dog to Kill all 3 types of Hookworms plus Prevent Heartworms is .0122 Mg. SO Zimecterin Gold Contains 7.42 Times More Ivermectin Than Any Dog needs to Control the Exact same Parasites and No more .
Zimecterin Gold ... Measured at the same weights noted on the Tube contains .454 Mg per Pound of Praziquantel which only Controls/Kills Adult "Horse Type" Tape Worm "Anoplocephala perfolita" which is Not Related to the Canine Type Tape Worms D caninum, T pisiformis, Echinococcus granulosus, E multilocularis ( Flea Host Tapeworm, Rabbit Host Tapeworm, Deer Feces Host Tapeworm, Fox, Coyote Host "Canis" Feces Tapeworm )
In order to Control/Kill the Canine Type Tapeworms require a Dosage of 2.5 Mg to 6 Mg. Per Pound of Praziquantel Meaning Zimecterin Gold is 7 times Less per pound that is Require to Treat Canine Tapeworms ..
Equimax ... Measured at the same weights noted on the Tube contains .109 Mg per Pound of Ivermectin and the Maxium Dosage of For a Dog to Kill all 3 types of Hookworms plus Prevent Heartworms is .0122 Mg. SO Equimax Contains 8.3 Times More Ivermectin Than Any Dog needs to Control the Exact same Parasites and No more .
Equimax ... Measured at the same weights noted on the Tube contains .987 Mg per Pound of Praziquantel which only Controls/Kills Adult "Horse Type" Tape Worm "Anoplocephala perfolita" which is Not Related to the Canine Type Tape Worms D caninum, T pisiformis, Echinococcus granulosus, E multilocularis ( Flea Host Tapeworm, Rabbit Host Tapeworm, Deer Feces Host Tapeworm, Fox, Coyote Host "Canis" Feces Tapeworm )
In order to Control/Kill the Canine Type Tapeworms require a Dosage of 2.5 Mg to 6 Mg. Per Pound of Praziquantel Meaning Equimax is 3 times Less per pound that is Require to Treat Canine Tapeworms ..
So to Sum it All up Ivermectin Only Works to Prevent Heartworms / and Will Kill all 3 Types of Adult Hookworms found in Canines ..
Horse Wormers !!!! Have way more Ivermectin then is Required to Prevent Heartworms/Adult Hookworms and Way too less Prazinquantel to Kill Adult Canine Type Tape Worms ..
And are NOT effective in Controlling or Killing Roundworms and Whipworms ...
If you Look in the Table Below the Only Additional Hookworm that Ivermectin will control over Pyrantel Promoate is The "Southern Hookworm" A braziliense .. Hookworms are found throughout North America, although A. braziliense is more common in semitropical and tropical areas, and U. stenocephala in the colder north. Their life cycle has an unusual twist – animals can be infected by ingestion of larvae either from contaminated soil or water; by eating an infected transport host; through larvae penetrating their skin, and by larvae infecting fetuses or the young via the uterus or mammary glands.
Remember All Dosages in the Below Table are in Mg per Kg of Dog Weight . to Convert to Mg. per Pound just devide to Dosage X 2.2
A little clarification
There is a lot of information here, but much of it is incorrect, and misinterpreted.
It is not true that Ivermectin is "Only Prevents Heartworms and 3 types of Hookworm in Dogs (Canines) A caninum, A braziliense, U stenocephala". If that were true it would not be used in the Equamax and other formulations for horses and other animals. Ivermectin actually is toxic to most worms and many other invertebrates. It does not always kill all parasites with one dose, and the dose for killing them is often different for each parasite. There are exceptions for this, especially tapeworms. These have a much different anatomy than other worms, and need a different chemical, like Praziquantel to kill them (it actually makes their cuticle ineffective and therefor they succumb to the digestive action in the gut). What I think the poster interpreted was what Ivermectin is recommended for - or it's labeled use in formulations for dogs, not the actual effectiveness of the chemical against parasites. So, yes, in heartworm formulation dose, it has little effect on a lot of other parasites. But in higher doses it is very effective. One study done in the 80's showed this: http://www.ncbi.nlm.nih.gov/pubmed/6897345 Even this one showed less effectiveness for Toxascaris leonina Though it seems from other studies to be effective when treated multiple times (there is also some evidence that it takes longer for the effects of treatment to be observable). There are lots of studies out there, and they are hard to interpret - the one quoted above though, is only for two species, and the dosages are low (more like heartworm preventive levels), so little can be interpreted about other worm species from it, or what higher levels would accomplish.
In addition, the formulations of products like Equimax are not meant for dogs. You would need to adjust a dosage based on dog physiology. This is much easier said than done. Also true. is that the proportions are not really meant for use in dogs.
If you are trying to use Ivermectin for dogs to eliminate all worms (non-tapeworms) you would have to find a dosage that would be appropriate. This information is not readily out there, because it is not approved for this use in dogs. There are studies that have shown that it can be effective, so you need to do some homework. Also, you may not find that one treatment is enough, and that subsequent treatments would need to be done. Or you would look for another drug for these worms.
Then the Praziquantel needs to be adjusted as well. If you get the correct dosage of Ivermectin, how much Praziquantel will that give the dog? Praziquantel has a wide tolerance level - the Toxic dose is LD50 acute, dogs: subcutaneously injected . >3000 mg/kg (http://parasitipedia.net). Also in higher doses, not even near that amount, dogs vomit. So you are relatively safe here, but it's not a 'recommended' use.
I know that the real reason for this posting is the high cost of even over-the-counter dewormers, especially for people who have lots of dogs. Given that, some may decide that using these horse medications is appropriate. Do so at your own risk!
I have not mentioned the side-effect of Ivermectin on some breeds (mainly herding dogs, and not likely in mixed breeds) - and that higher doses can be fatal in susceptible individuals (not usually at heartworm prevention levels). There is now a test for the mutation that is responsible for this (the dog can not eliminate the chemical from the brain, it's not truly a blood-brain barrier problem). So if you have these breeds you can test for it. You can look this up yourself...
You can get the 1% ivomec liquid & give 0.1 ml/10 lbs. body wt.
I tried the paste last summer when I ran out of my ivomec mix. I overdosed my dogs accidentally. I'll never give them the paste again. It took them about a week and a half to get back to normal. I mix 20ml of ivomec with 80ml of propylene glycol and dose the 1ml per 20lb of body weight.